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  4. PGD Antibody

PGD Antibody

  • 中文名稱：
    PGD兔多克隆抗體
  • 貨號：
    CSB-PA787749
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from A549 cells, using PGD antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PGD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PGD
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human PGD.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.
  • 基因功能參考文獻：
    1. identified that 6-phosphogluconate dehydrogenase (6PGD) is critically involved in the development of anaplastic thyroid cancer (ATC) resistance to doxorubicin. 6PGD inhibition disrupts metabolic reprogramming in doxorubicin-resistant ATC cells. PMID: 29534964
    2. Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1-AMPK signalling. PMID: 26479318
    3. copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues PMID: 24125036
    4. Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells. PMID: 25042803
    5. Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation. PMID: 23973484
    6. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence PMID: 22677172
    7. Data suggest that the affinity of Nox2 for NADPH is increased in the presence of 6PGDH on cell stimulation. PMID: 21444627
    8. Hsa-miR-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders. PMID: 20675101

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    6-phosphogluconate dehydrogenase family
  • 數(shù)據庫鏈接：

    HGNC: 8891

    OMIM: 172200

    KEGG: hsa:5226

    STRING: 9606.ENSP00000270776

    UniGene: Hs.464071