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PGM1 Antibody

  • 中文名稱：
    PGM1兔多克隆抗體
  • 貨號：
    CSB-PA017866HA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PGM1 antibody at 6µg/ml
      Lane 1: U251 whole cell lysate
      Lane 2: U937 whole cell lysate
      Lane 3: Jurkat whole cell lysate
      Lane 4: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 62, 64, 41 kDa
      Observed band size: 62 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017866HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017866HA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA017866HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PGM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PGM1
  • 別名：
    CDG1T antibody; Glucose phosphomutase 1 antibody; GSD14 antibody; OTTHUMP00000010519 antibody; OTTHUMP00000010520 antibody; PGM 1 antibody; PGM1 antibody; PGM1_HUMAN antibody; Phosphoglucomutase 1 antibody; Phosphoglucomutase-1 antibody; Phosphoglucomutase1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Phosphoglucomutase-1 protein (1-562AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PGM1 Antibody (CSB-PA017866HA01HU)，的標(biāo)記方式是Non-conjugated。對于PGM1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA017866HB01HU PGM1 Antibody, HRP conjugated ELISA
    FITC CSB-PA017866HC01HU PGM1 Antibody, FITC conjugated
    Biotin CSB-PA017866HD01HU PGM1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    This enzyme participates in both the breakdown and synthesis of glucose.
  • 基因功能參考文獻(xiàn)：
    1. PGM1 deficiency has been recognized as a cause of the congenital disorders of glycosylation. PMID: 29858906
    2. The structural perturbation resulting from mutation of this single amino acid reveals the molecular mechanism underlying PGM1 deficiency in these missense variants. PMID: 28117557
    3. Homozygous mutation in the PGM1 gene is associated with PGM1 deficiency. PMID: 26768186
    4. analysis of the structural basis of PGM1 enzyme dysfunction in PGM1 deficiency PMID: 26972339
    5. both PGM1 protein misfolding and catalytic impairment may play a role in PGM1 deficiency PMID: 25288802
    6. PGM1 is required for sustained cell growth during nutritional changes PMID: 24952355
    7. Phosphoglucomutase 1 deficiency, previously identified as a glycogenosis, is also a congenital disorder of glycosylation. PMID: 24499211
    8. The analysis involved the data on nine polymorphic codominant loci: HP, GC, TF, PI, PGM1, GLO1, C3, ACP1, and ESD. The loci were selected by significance of differences in genotype frequencies between tuberculosis patients and healthy controls PMID: 12942785
    9. Results report a novel human protein, calphoglin, which activates inorganic pyrophosphatase (IPP) and enhances phosphoglucomutase activity through the activated IPP. PMID: 15522220
    10. During extrauterine life, females carrying the PGM1*2 allele are relatively protected from extreme body mass increase, and during intrauterine life, PGM1*2/*2 homozygotes show a tendency to low body mass increase. PMID: 18091362
    11. There is a correlation between glomerular expression of MCP-1 and PGM1 and worsening renal prognosis in paediatric lupus nephritis. PMID: 18495743
    12. ZASP/Cypher anchors PGM1 to Z-disc under conditions of stress. The impaired binding of PGM1 to ZASP/Cypher might be involved in the pathogenesis of dilated cardiomyopathy. PMID: 19377068

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  • 相關(guān)疾病：
    Congenital disorder of glycosylation 1T (CDG1T)
  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm.
  • 蛋白家族：
    Phosphohexose mutase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8905

    OMIM: 171900

    KEGG: hsa:5236

    UniGene: Hs.1869