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  4. PHF21A Antibody, FITC conjugated

PHF21A Antibody, FITC conjugated

  • 中文名稱：
    PHF21A兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA017911LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PHF21A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PHF21A
  • 別名：
    BHC80a antibody; BM-006 antibody; BRAF35-HDAC complex protein BHC80 antibody; BRAF35/HDAC2 complex (80 kDa) antibody; KIAA1696 antibody; PF21A_HUMAN antibody; PHD finger protein 21A antibody; PHF21A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PHD finger protein 21A protein (312-487AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
  • 基因功能參考文獻：
    1. this case lends further support that haploinsufficiency of PHF21A contributes to the intellectual disability and craniofacial abnormalities in PSS and that there are other genes in the region which likely contribute to the behavioral phenotype in this syndrome. PMID: 28127865
    2. we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2. PMID: 22770980
    3. Presumably serves as a scaffold protein in BHC in neuronal as well as non-neuronal cells. Possible role in spermatogenesis. PMID: 15325272
    4. the recovery of neurosecretion depends on the reciprocal level of BHC80 and REST, with BHC80 working as a negative modulator of REST repression PMID: 19439607
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in brain. Expressed at lower level in other tissues, including heart, kidney, liver, lung and skeletal muscle. Abundantly expressed in fetal brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24156

    OMIM: 608325

    KEGG: hsa:51317

    STRING: 9606.ENSP00000398824

    UniGene: Hs.502458