PHIP Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q8WWQ0
基因名：

PHIP
別名：

PHIP antibody; DCAF14 antibody; WDR11 antibody; PH-interacting protein antibody; PHIP antibody; DDB1- and CUL4-associated factor 14 antibody; IRS-1 PH domain-binding protein antibody; WD repeat-containing protein 11 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse
免疫原：

Human PHIP
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.
基因功能參考文獻(xiàn)：
1. The replication initiation determinant protein PHIP modulates replication by recruiting CUL4 to chromatin. PMID: 30018425
2. These results provide further support for PHIP as a molecular prognostic marker of melanoma, and reveal a significant linkage between PHIP levels and ulceration. PMID: 24005052
3. The PHIP gene resides on 6q14.1, and although 6q loss has been observed in melanoma, the PHIP locus was preserved in melanoma cell lines and patient samples, and its overexpression was an independent adverse predictor of survival in melanoma patients. PMID: 22511720
亞細(xì)胞定位：

Nucleus.
組織特異性：

Expressed in myeloma and epidermoid carcinoma cell lines.
數(shù)據(jù)庫鏈接：

HGNC: 15673

OMIM: 612870

KEGG: hsa:55023

STRING: 9606.ENSP00000275034

UniGene: Hs.511817