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  4. PIH1D1 Antibody, FITC conjugated

PIH1D1 Antibody, FITC conjugated

  • 中文名稱：
    PIH1D1兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA889130LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) PIH1D1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PIH1D1
  • 別名：
    NOP17 antibody; Nucleolar protein 17 homolog antibody; PIH1 domain containing 1 antibody; PIH1 domain containing protein 1 antibody; PIH1 domain-containing protein 1 antibody; PIH1D1 antibody; PIHD1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PIH1 domain-containing protein 1 protein (1-290AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles. Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription. Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1. Positively regulates the assembly and activity of the mTORC1 complex.
  • 基因功能參考文獻：
    1. We propose that protein complexes assembled by the R2TP complex are defined by phosphorylation of a specific motif and recognition by the PIH1D1 subunit PMID: 24656813
    2. PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription. PMID: 24036451
    3. Human PIH1 domain-containing protein 1 (PIH1) interacts directly with histone H4 and recruits the Brg1-SWI/SNF complex via SNF5 to human rRNA genes. PMID: 22368283
    4. this study investigated the interaction between RPAP3 and PIH1D1. PMID: 23159623
    5. PIH1D1 may stabilize SNF5 by attenuating its proteasome degradation pathway. PMID: 20078948
    6. These results suggest that PIH1D1 may also function as a novel modulator of apoptosis pathway. PMID: 21078300
    7. Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    PIH1 family
  • 組織特異性：
    Expressed at low levels in normal mammary epithelial cells (at protein level). Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen
  • 數據庫鏈接：

    HGNC: 26075

    OMIM: 611480

    KEGG: hsa:55011

    STRING: 9606.ENSP00000262265

    UniGene: Hs.5245