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PLAGL2 Antibody

  • 中文名稱：
    PLAGL2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA970081
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA970081(PLAGL2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA970081(PLAGL2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PLAGL2
  • 別名：
    C2H2 type zinc finger protein antibody; KIAA0198 antibody; PLAGL2 antibody; PLAL2_HUMAN antibody; Pleiomorphic adenoma gene-like 2 antibody; Pleiomorphic adenoma-like protein 2 antibody; Zinc finger protein PLAGL2 antibody; ZNF900 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human PLAGL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Shows weak transcriptional activatory activity.
  • 基因功能參考文獻(xiàn)：
    1. overexpression of miR-449a inhibited the expression of PLAGL2 significantly and the knockdown of PLAGL2 expression inhibited the breast cancer cell proliferation and metastasis PMID: 29653747
    2. increased expression correlates to prostate cancer progression following radical prostatectomy and may serve as novel poor prognostic marker PMID: 27537362
    3. Our findings indicated that PLAGL2 might be a very upstream key molecule regulating Epithelial-mesenchymal transition involved in Wnt/bcatenin signaling pathway in Colorectal adenocarcinoma PMID: 28259923
    4. Our findings indicate that PALGL2 serves as a tumor oncoprotein in the development and progression of colorectal cancer PMID: 25031728
    5. PLAGL2 expression induces lamellipodia formation and disruption of stress fiber formation. PMID: 24675530
    6. PLAGL2 regulate cell cycle and apoptosis via activation of the p53 family member, p73, in human promonocytic U937 cells. PMID: 22076304
    7. Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling PMID: 20478531
    8. The data identify PC2 as a novel PLAGL2-binding protein and important mediator of PLAGL2 transactivation. PMID: 20025940
    9. PLAGL2 may modulate SP-C expression during lung development. PMID: 15361364
    10. Coexpression of Tip60 and PLAGL2 completely abolishes the sumoylation of PLAGL2. PMID: 17551969
    11. Nuclear PLAGL2 occupied and transactivated the endogenous SP-C promoter in hypoxic lung cells.These results further suggest that PLAGL2 is an oxidative stress responding regulator in lung cells. PMID: 17618602
    12. This study thus uncovers a novel function of PLAGL2 as an oncoprotein through regulating the stability of Pirh2. PMID: 17950244
    13. These data suggests that Ubc9 can function as a co-factor of PLAGL2, uncoupling from its enzymatic activity, to mediate PLAGL2 interactive SP-C promoter activity. PMID: 18655774
    14. Increased cell injury and/or death could be caused directly by the upregulation of bNip3, a preapoptotic molecule that dimerizes with Bcl-2, or indirectly by the aberrant expression of SP-C-induced endoplasmic reticulum stress in epithelial cells. PMID: 19574421

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9047

    OMIM: 604866

    KEGG: hsa:5326

    STRING: 9606.ENSP00000246229

    UniGene: Hs.154104