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  4. POLG2 Antibody

POLG2 Antibody

  • 中文名稱：
    POLG2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA826673
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using POLG2 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) POLG2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POLG2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human POLG2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Mitochondrial polymerase processivity subunit. It regulates the polymerase and exonuclease activities promoting processive DNA synthesis. Binds to ss-DNA.
  • 基因功能參考文獻(xiàn)：
    1. This is the first report of a patient with a homozygous mutation in POLG2 and with a clinical presentation of severe hepatic failure and mitochondrial depletion. PMID: 27592148
    2. Results show that polymorphisms at POLG2 and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes. PMID: 26403317
    3. Mitochondrial DNA (mtDNA) content plays an important role in energy production and sustaining normal physiological function. PMID: 24524965
    4. The authors describe the molecular characterization of a potential dominant POLG2 mutation (p.R369G) in a patient with autosomal dominant progressive external ophthalmoplegia and multiple mtDNA deletions. PMID: 22155748
    5. Data show that rs17650301 in POLG2 is a good candidate marker for UBC invasiveness in Japanese males. PMID: 21734712
    6. The biochemical analysis helps explain the pathogenesis of POLG2 mutations in mitochondrial disease. PMID: 21555342
    7. human pol gammaB exhibits a catalytic subunit- and substrate DNA-dependent dimerization. PMID: 19858216
    8. PolB gamma can bind double-stranded DNA and may play a role in DNA replication or repair PMID: 12379656
    9. Study represents the first structure-function analysis of the thumb subdomain in pol gamma and examines the consequences of mitochondrial disease mutations in this region. PMID: 19478085
    10. Both increased and decreased expression of POLGbeta altered nucleoid structure and precipitated a marked decrease in 7S DNA molecules, which form short displacement-loops on mitochondrial DNA. PMID: 19625489

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  • 相關(guān)疾?。?/div>
    Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 4 (PEOA4)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9180

    OMIM: 604983

    KEGG: hsa:11232

    STRING: 9606.ENSP00000442563

    UniGene: Hs.437009