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POLR3C Antibody

  • 中文名稱：
    POLR3C兔多克隆抗體
  • 貨號：
    CSB-PA871578LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: POLR3C antibody at 2µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: Mouse brain tissue
      Lane 4: THP-1 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 61 kDa
      Observed band size: 61 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) POLR3C Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    POLR3C
  • 別名：
    DNA directed III 62 kDa polypeptide antibody; DNA-directed RNA polymerase III subunit C antibody; DNA-directed RNA polymerase III subunit rpc3 antibody; POLR3C antibody; Polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody; RNA polymerase C subunit 3 antibody; RNA polymerase III 62 kDa subunit antibody; RNA polymerase III C62 subunit antibody; RNA polymerase III subunit C3 antibody; RPC3 antibody; RPC3_HUMAN antibody; RPC62 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human DNA-directed RNA polymerase III subunit RPC3 protein (1-534AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，POLR3C Antibody (CSB-PA871578LA01HU)，的標記方式是Non-conjugated。對于POLR3C Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA871578LB01HU POLR3C Antibody, HRP conjugated ELISA
    FITC CSB-PA871578LC01HU POLR3C Antibody, FITC conjugated
    Biotin CSB-PA871578LD01HU POLR3C Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner.
  • 基因功能參考文獻：
    1. monogenic or digenic POLR3A and POLR3C deficiencies confer increased susceptibility to severe VZV disease in otherwise healthy children, providing evidence for an essential role of a DNA sensor in human immunity PMID: 28783042
    2. The study reports the crystal structure of RPC62. PMID: 21358628
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Eukaryotic RPC3/POLR3C RNA polymerase subunit family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30076

    OMIM: 617454

    KEGG: hsa:10623

    STRING: 9606.ENSP00000334564

    UniGene: Hs.515768