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PPM1K Antibody

  • 中文名稱：
    PPM1K兔多克隆抗體
  • 貨號：
    CSB-PA003835
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using PP2Cκ Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PPM1K
  • 別名：
    BDP antibody; mitochondrial antibody; MSUDMV antibody; PP2C domain containing protein phosphatase 1K antibody; PP2C domain-containing protein phosphatase 1K antibody; PP2C kappa antibody; PP2C like mitochondrial protein antibody; PP2C type mitochondrial phosphoprotein phosphatase antibody; PP2C-kappa antibody; PP2C-like mitochondrial protein antibody; PP2C-type mitochondrial phosphoprotein phosphatase antibody; PP2Ckappa antibody; PP2CM antibody; PPM1K antibody; PPM1K_HUMAN antibody; Protein phosphatase 1K antibody; Protein phosphatase 1K; mitochondrial antibody; Protein phosphatase 2C isoform kappa antibody; Protein phosphatase Mg2+/Mn2+ dependent 1K antibody; PTMP antibody; UG0882E07 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PP2Cκ.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.
  • 基因功能參考文獻(xiàn)：
    1. Branched chain amino acids related genetic variant rs1440581 was associated with an increased risk of incident T2 Diabetes in a Chinese population. This variant might modify effect of weight gain on development in Insulin resistance. PMID: 29855804
    2. PPM1K rs1440581 may affect changes in glucose metabolism during weight loss, and this effect is dependent on dietary fat and carbohydrate intakes. PMID: 28768654
    3. miR-204 and miR-211 directly repress PPM1K expression via 3'UTR. PMID: 26592513
    4. Overweight people with the C allele of the branched-chain amino acid/aromatic amino acid ratio-associated variant rs1440581 may benefit less in weight loss and improved insulin sensitivity than those without it on a energy-restricted high-fat diet. PMID: 23446828
    5. The 2.4 A PP2Cm structure reveals a central beta-sandwich with two bound metal ions in the active-site cleft. PMID: 22291014
    6. A novel member of human protein phosphatase 2C gene family named PP2Ckappa was isolated from a human fetal brain cDNA library. PMID: 16685424
    7. The cloned phosphatase has a mitochondrial leader sequence and its amino acid sequence places it in the PP2C family like two known mitochondrial phosphatases. PMID: 17336929

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  • 相關(guān)疾病：
    Maple syrup urine disease, mild variant (MSUDMV)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    PP2C family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25415

    OMIM: 611065

    KEGG: hsa:152926

    STRING: 9606.ENSP00000295908

    UniGene: Hs.43744