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PPP1R3A Antibody

  • 中文名稱：
    PPP1R3A兔多克隆抗體
  • 貨號(hào)：
    CSB-PA613701DSR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA613701DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA613701DSR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PPP1R3A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Glycogen and sarcoplasmic reticulum binding subunit, skeletal muscle antibody; Glycogen associated regulatory subunit of protein phosphatase 1 antibody; GM antibody; PP1G antibody; PPP1R3 antibody; PPP1R3A antibody; PPR3A_HUMAN antibody; Protein phosphatase 1 glycogen-associated regulatory subunit antibody; Protein phosphatase 1 glycogen-targeting subunit, muscle antibody; Protein phosphatase 1 regulatory subunit 3A antibody; Protein phosphatase 1 regulatory subunit GM antibody; protein phosphatase 1, regulatory (inhibitor) subunit 3A antibody; Protein phosphatase 1, regulatory subunit 3 antibody; Protein phosphatase type-1 glycogen targeting subunit antibody; RG1 antibody; Serine /threonine specific protein phosphatase antibody; Type 1 protein phosphatase skeletal muscle glycogen targeting subunit antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Protein phosphatase 1 regulatory subunit 3A protein (900-1080AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Seems to act as a glycogen-targeting subunit for PP1. PP1 is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Plays an important role in glycogen synthesis but is not essential for insulin activation of glycogen synthase.
  • 基因功能參考文獻(xiàn)：
    1. Variant in PPP1R3A is associated with type 2 diabetes. PMID: 29948331
    2. In the univariate analyses, TP53, PPP1R3A, and KMT2B were significantly more frequently mutated in interval cancers than in screen-detected cancers. PMID: 27587435
    3. results demonstrate that hScrib acts as a scaffold to integrate the control of the PP1gamma and ERK signaling pathways and explains how disruption of hScrib localisation can contribute towards the development of human malignancy PMID: 23359326
    4. A joint effect between the Asp905 and BMI increases the risk of type 2 diabetes, and Asp905Tyr and ARE polymorphism of PPP1R3 gene are not the major diabetogenic gene variants in Chinese population. PMID: 11793847
    5. G(M) promotes glycogen storage and inversely regulates glycogen synthase and glycogen phosphorylase activities, while, specifically, synthase phosphatase activity of G(M)-PP1 is inhibited by glycogen. PMID: 12941760
    6. Among the largest cohort of nondiabetic subjects (Caucasian, n = 112), the presence of the deletion allele (ARE-2) was associated with insulin resistance and hyperandrogenemia. PMID: 15181086
    7. Inactivation of PPP1R3 gene is associated with tumor progression and metastasis of colorectal cancers PMID: 15870946
    8. PPP1R3A C1984DeltaAG (stop codon 668) isthe 1st prevalent mutation that directly impairs glycogen synthesis & decreases glycogen levels in human skeletal muscle. It is present in approximately 1 in 70 UK whites. PMID: 18232732

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  • 相關(guān)疾?。?/div>
    Diabetes mellitus, non-insulin-dependent (NIDDM)
  • 亞細(xì)胞定位：
    Membrane; Single-pass membrane protein.
  • 組織特異性：
    Skeletal muscle and heart.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9291

    OMIM: 125853

    KEGG: hsa:5506

    STRING: 9606.ENSP00000284601

    UniGene: Hs.458309