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PRCP Antibody

  • 中文名稱：
    PRCP兔多克隆抗體
  • 貨號：
    CSB-PA018636LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA018636LA01HU at 1:166, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PRCP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Angiotensinase C antibody; HUMPCP antibody; Lysosomal carboxypeptidase C antibody; Lysosomal Pro X carboxypeptidase antibody; Lysosomal Pro-X carboxypeptidase antibody; MGC2202 antibody; PCP antibody; PCP_HUMAN antibody; PRCP antibody; Proline carboxypeptidase antibody; Prolylcarboxypeptidase (angiotensinase C) antibody; Prolylcarboxypeptidase antibody; prolylcarboxypeptidase isoform 1 preproprotein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Lysosomal Pro-X carboxypeptidase protein (347-443AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PRCP Antibody (CSB-PA018636LA01HU)，的標記方式是Non-conjugated。對于PRCP Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA018636LB01HU PRCP Antibody, HRP conjugated ELISA
    FITC CSB-PA018636LC01HU PRCP Antibody, FITC conjugated
    Biotin CSB-PA018636LD01HU PRCP Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
  • 基因功能參考文獻：
    1. For the first time, PRCP is identified as an apelin-cleaving enzyme. PMID: 27449720
    2. The decrease in PRCP levels in the first 24 h after stroke onset is associated with stroke severity and an unfavourable short-term stroke outcome PMID: 25370794
    3. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation. PMID: 25324000
    4. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population. PMID: 22679278
    5. PRCP regulates cell growth, angiogenesis, and the response to vascular injury PMID: 23744584
    6. analysis of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors PMID: 22079761
    7. PRCP as a resistance factor for 4OHTAM resistance in estrogen receptor-positive breast cancer cells. PMID: 21087932
    8. A single peptide, with the sequence YPRPIHPA, as a novel substrate for PRCP in human cerebrospinal fluid. PMID: 20517885
    9. Purified PrCP yielded crystals belonging to space group R32, with unit-cell parameters a = b = 181.14, c = 240.13 A, that diffracted to better than 2.8 A resolution. PMID: 20516604
    10. A structure-based alignment with the previously undescribed structure of DPP7 illuminates the mechanism of orthogonal substrate specificity of PRCP and DPP7. PMID: 20540760
    11. Data suggest that the E112D polymorphism in the PRCP gene may be a useful genetic marker to predict the antihypertensive effect of short-term benazepril treatment in hypertensive patients. PMID: 20079160
    12. PRCP appears to be a HUVEC-associated prekallikrein activator. PMID: 11830581
    13. Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator. PMID: 12123826
    14. recombinant protein, identical to enzyme from human umbilical vein endothelial cells, is a prekallikrein activator. PMID: 14996700
    15. Prolylcarboxypepdiase E112D (rs2298668)D allele alone and jointly with chronic hypertension were associated with a significantly increased risk of preeclampsia PMID: 16681991
    16. role in regulation cardiovascular tone; proinflammatory agent PMID: 18396440
    17. These investigations showed that the C-terminal region of the rPRCP(40) contributes to PRCP's catalytic function, and provided additional experimental evidence for this suggestion. PMID: 18656443

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  • 亞細胞定位：
    Lysosome.
  • 蛋白家族：
    Peptidase S28 family
  • 組織特異性：
    Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9344

    OMIM: 176785

    KEGG: hsa:5547

    STRING: 9606.ENSP00000377055

    UniGene: Hs.523936