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  4. PRKACG Antibody

PRKACG Antibody

  • 中文名稱：
    PRKACG兔多克隆抗體
  • 貨號：
    CSB-PA925968
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COLO205 cells, using KAPCG antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PRKACG Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human KAPCG.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
  • 基因功能參考文獻：
    1. The missense p.74Ile>Met PRKACG mutation is associated with a marked defect in proplatelet formation and a low level in filamin A in megakaryocytes. PMID: 25061177
    2. PKA-mediated phosphorylation of GPIbbeta at Ser(166) negatively regulates VWF binding to GPIb-IX and is one of the mechanisms by which PKA mediates platelet inhibition PMID: 12361948
    3. Results suggest that Cgamma and Calpha differ in structure and function in vitro, supporting the hypothesis that functionally different C-subunit isozymes could affect cAMP signal transduction downstream of protein kinase A activation. PMID: 15039079
  • 相關(guān)疾病：
    Bleeding disorder, platelet-type 19 (BDPLT19)
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, cAMP subfamily
  • 組織特異性：
    Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9382

    OMIM: 176893

    KEGG: hsa:5568

    STRING: 9606.ENSP00000366488

    UniGene: Hs.158029