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  4. PSD Antibody, FITC conjugated

PSD Antibody, FITC conjugated

  • 中文名稱：
    PSD兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA018842LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PSD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    PSD antibody; EFA6 antibody; EFA6A antibody; KIAA2011 antibody; PSD1 antibody; TYL antibody; PH and SEC7 domain-containing protein 1 antibody; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 antibody; Exchange factor for ARF6 antibody; Exchange factor for ARF6 A antibody; Pleckstrin homology and SEC7 domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PH and SEC7 domain-containing protein 1 protein (247-489AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling.
  • 基因功能參考文獻：
    1. Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis. PMID: 26330566
    2. PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention. PMID: 25355626
    3. EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6-GTP with a domain of EFA6 and monitors the activation of Arf1 and Arf6 differentially PMID: 25114232
    4. EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis. PMID: 23603394
    5. Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis. PMID: 22179719
    6. Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation. PMID: 22002136
    7. Pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes. PMID: 17579087

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  • 亞細(xì)胞定位：
    Cell membrane. Cell projection, ruffle membrane. Cleavage furrow.
  • 蛋白家族：
    PSD family
  • 組織特異性：
    Isoform 2 is expressed in the brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9507

    OMIM: 602327

    KEGG: hsa:5662

    STRING: 9606.ENSP00000020673

    UniGene: Hs.154658