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  4. PSMB11 Antibody

PSMB11 Antibody

  • 中文名稱：
    PSMB11兔多克隆抗體
  • 貨號：
    CSB-PA018878GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PSMB11
  • 別名：
    BETA5T antibody; Proteasome (prosome, macropain) subunit beta type 11 antibody; Proteasome subunit beta 5T antibody; Proteasome subunit beta type-11 antibody; Proteasome subunit beta-5t antibody; PSB11_HUMAN antibody; PSMB11 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human PSMB11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Incorporated instead of PSMB5 or PSMB8, this unit reduces the chymotrypsin-like activity of the proteasome. Plays a pivotal role in development of CD8-positive T cells.
  • 基因功能參考文獻：
    1. We analysed thymic tissues from patients with trisomy 13 (n = 4), trisomy 18 (n = 14) and trisomy 21 (n = 13) for histological alterations, and for the expression of functionally important molecules such as beta5t, a thymoproteasome subunit, and cathepsins. PMID: 25556590
    2. Histological diversity of type AB thymoma correlates with expression of a functional marker beta5t and abundance of TdT-positive lymphocytes. PMID: 24293611
    3. provide the first evidence that the mechanism underlying BTZ resistance in these tumor cells is impaired binding of BTZ to the mutant beta5 subunit of the proteasome PMID: 21941364
    4. Proteasome beta5t is expressed in most type B and in some type AB thymomas and is a marker useful in differentiating type B3 thymomas from thymic carcinomas when used in combination with other diagnostic markers. PMID: 21836487
    5. results suggest a key role for beta5t in generating the MHC class I-restricted CD8(+) T cell repertoire during thymic selection PMID: 17540904
    6. Human beta5t was expressed in approximately 80% of cortical thymic epithelial cells and some cortical dendritic cells PMID: 19289856

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Peptidase T1B family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 31963

    OMIM: 611137

    KEGG: hsa:122706

    STRING: 9606.ENSP00000386212

    UniGene: Hs.508918