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  4. PSMC3 Antibody

PSMC3 Antibody

  • 中文名稱：
    PSMC3兔多克隆抗體
  • 貨號：
    CSB-PA040034
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    PSMC3
  • 別名：
    26S protease regulatory subunit 6A antibody; 26S proteasome AAA-ATPase subunit RPT5 antibody; Human immunodeficiency virus tat transactivator binding protein 1 antibody; MGC8487 antibody; Proteasome (prosome macropain) 26S subunit ATPase 3 antibody; Proteasome 26S ATPase subunit 3 antibody; Proteasome 26S subunit ATPase 3 antibody; Proteasome subunit P50 antibody; PRS6A_HUMAN antibody; PSMC 3 antibody; PSMC3 antibody; Tat binding protein 1 antibody; TAT-binding protein 1 antibody; TBP-1 antibody; TBP1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human PSMC3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC3 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
  • 基因功能參考文獻(xiàn)：
    1. These data suggest the existence of a negative feedback loop involving Akt/PKB that might act as a sensor to modulate TBP-1 levels in proliferating cells. PMID: 21991300
    2. 19S ATPase S6b (S6'/TBP1) binds CIITApIV in an S6a-dependent fashion and has effects similar to S6a on CIITApIV histone acetylation. PMID: 19853614
    3. role in E3 ubiquitin ligase function of the von Hippel-Lindau protein PMID: 14556007
    4. molecular modeling of DNA:TATA element binding protein (TBP) interactions after treatment with 2-Chloro-2'-deoxyadenosine PMID: 14610662
    5. Tat-binding protein-1 binds to human ARF tumor suppressor and has a role in control of cell proliferation PMID: 14665636
    6. In normal cells, unmodified S12 associates with the 26S proteasome, while modified S12-M does not. PMID: 15221960
    7. The stabilization effect exerted by TBP-1 requires an intact N-terminal 39 amino acids in ARF and occurs independently from N-terminal ubiquitination of the protein. PMID: 17334400
    8. Heplipin induced KG-1 cell apoptosis is related with Wntl3 and ATPase3. PMID: 17649721
    9. findings suggest that a component of 19S regulatory particles directly binds AR and might participate in AR-mediated transcriptional activation in cooperation with TBPIP. PMID: 19325002

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    AAA ATPase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9549

    OMIM: 186852

    KEGG: hsa:5702

    STRING: 9606.ENSP00000298852

    UniGene: Hs.250758