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PTGR1 Antibody

  • 中文名稱：
    PTGR1兔多克隆抗體
  • 貨號：
    CSB-PA018983LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA018983LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA018983LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PTGR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTGR1
  • 別名：
    15-oxoprostaglandin 13-reductase antibody; FLJ99229 antibody; leukotriene B4 12-hydroxydehydrogenase antibody; LTB4DH antibody; MGC34943 antibody; NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody; PGR1 antibody; PRG-1 antibody; Prostaglandin reductase 1 antibody; Ptgr1 antibody; PTGR1_HUMAN antibody; RP11-16L21.1 antibody; ZADH3 antibody; zinc binding alcohol dehydrogenase domain containing 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Prostaglandin reductase 1 protein (202-282AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PTGR1 Antibody (CSB-PA018983LA01HU)，的標記方式是Non-conjugated。對于PTGR1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA018983LB01HU PTGR1 Antibody, HRP conjugated ELISA
    FITC CSB-PA018983LC01HU PTGR1 Antibody, FITC conjugated
    Biotin CSB-PA018983LD01HU PTGR1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles.
  • 基因功能參考文獻：
    1. The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder. PMID: 28088550
    2. selenium had only a minor influence on prostaglandin reductase 1 (PTGR1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and protein levels PMID: 25179160
    3. These results situate PtGR-1 as a critical modulator of both the steady state levels and signaling activities of fatty acid nitroalkenes in vivo. PMID: 23878198
    4. Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response. PMID: 20804502
    5. restoration of expression in enzyme-negative lung cancer cell lines induces apoptosis and growth inhibition PMID: 19595472

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    NADP-dependent oxidoreductase L4BD family
  • 組織特異性：
    High expression in the kidney, liver, and intestine but not in leukocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18429

    OMIM: 601274

    KEGG: hsa:22949

    STRING: 9606.ENSP00000311572

    UniGene: Hs.584864