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PTGR2 Antibody

  • 中文名稱：
    PTGR2兔多克隆抗體
  • 貨號：
    CSB-PA018984LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate(30μg), MCF7 whole cell lysate(30μg), PC-3 whole cell lysate(30μg), A549 whole cell lysate(20μg), Mouse Heart tissue lysate(30μg)
      All lanes:PTGR2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 39, 20 kDa
      Observed band size: 39 kDa
      Exposure time: 120s
    • IHC image of CSB-PA018984LA01HU diluted at 1:165 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
    • IHC image of CSB-PA018984LA01HU diluted at 1:165 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB. Secondary antibody only control: uses 1% BSA instead of primary antibody
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PTGR2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PTGR2
  • 別名：
    15 oxoprostaglandin 13 reductase antibody; 15 oxoprostaglandin delta 13 reductase antibody; 15-oxoprostaglandin 13-reductase antibody; DKFZp686P10120 antibody; FLJ39091 antibody; FLJ99229 antibody; PGR 2 antibody; PGR2 antibody; PRG-2 antibody; Prostaglandin reductase 2 antibody; PTGR 2 antibody; PTGR2 antibody; PTGR2_HUMAN antibody; Zinc binding alcohol dehydrogenase domain containing 1 antibody; Zinc binding alcohol dehydrogenase domain containing protein 1 antibody; Zinc-binding alcohol dehydrogenase domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Prostaglandin reductase 2 protein (206-282AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PTGR2 Antibody (CSB-PA018984LA01HU)，的標記方式是Non-conjugated。對于PTGR2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA018984LB01HU PTGR2 Antibody, HRP conjugated ELISA
    FITC CSB-PA018984LC01HU PTGR2 Antibody, FITC conjugated
    Biotin CSB-PA018984LD01HU PTGR2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:3000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.
  • 基因功能參考文獻：
    1. Silencing of PTGR2 expression enhances reactive oxygen species production, suppresses pancreatic cell proliferation, and promotes cell death through increasing 15-keto-PGE2. PMID: 26820738
    2. Functional data and clinical relevance for the role of PTGR2 in gastric cancer, are provided. PMID: 22998775
    3. Cloning and tissue distribution of a splicing variant ZADH1b. PMID: 15004468
    4. Besides targeting cyclooxygenase, indomethacin inhibits PTGR2 with a binding mode similar to that of 15-keto-PGE(2). PMID: 19000823
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    NADP-dependent oxidoreductase L4BD family
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20149

    OMIM: 608642

    KEGG: hsa:145482

    STRING: 9606.ENSP00000267568

    UniGene: Hs.632344