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PYHIN1 Antibody

  • 中文名稱：
    PYHIN1兔多克隆抗體
  • 貨號：
    CSB-PA746957LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: PYHIN1 antibody at 6µg/ml + Mouse small intestine tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 55, 52, 51, 27, 26 kDa
      Observed band size: 56, 22, 84 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PYHIN1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PYHIN1
  • 別名：
    IFIX_HUMAN antibody; Interferon-inducible protein X antibody; Pyhin1 antibody; Pyrin and HIN domain-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，PYHIN1 Antibody (CSB-PA746957LA01HU)，的標(biāo)記方式是Non-conjugated。對于PYHIN1 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA746957LB01HU PYHIN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA746957LC01HU PYHIN1 Antibody, FITC conjugated
    Biotin CSB-PA746957LD01HU PYHIN1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrates that IFIX antiviral functions work in part via viral transcriptional suppression and that HSV-1 has acquired mechanisms to block its functions via proteasome-dependent degradation. PMID: 28077445
    2. a new member of the hematopoietic interferon (IFN)-inducible nuclear protein. Six different alternatively spliced forms are transcribed from the IFIX gene PMID: 15122330
    3. IFIX alpha1 isoform functions as a tumor suppressor by repressing HDM2 function PMID: 16479015
    4. IFIXalpha suppressed the invasion activity of MDA-MB-468 breast cancer cells, and its inhibitory effect was reversed by the knockdown of maspin PMID: 18247378
  • 亞細(xì)胞定位：
    [Isoform 1]: Nucleus, nucleoplasm.; [Isoform 3]: Nucleus, nucleoplasm.; [Isoform 5]: Nucleus. Nucleus speckle.
  • 蛋白家族：
    HIN-200 family
  • 組織特異性：
    Expressed in spleen, lymph node and peripheral blood leukocytes, and at lower levels in thymus, bone marrow and fetal liver. Down-regulated in breast tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28894

    OMIM: 612677

    KEGG: hsa:149628

    STRING: 9606.ENSP00000357122

    UniGene: Hs.710248