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  4. Phospho-FBXL3 (Ser320) Antibody

Phospho-FBXL3 (Ser320) Antibody

  • 中文名稱：
    磷酸化-FBXL3 (Ser320)兔多克隆抗體
  • 貨號：
    CSB-PA976364
  • 規(guī)格：
    ￥2454
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) FBXL3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    FBXL3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Humann,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 320 (S-V-S(p)-K-D) derived from Human FBXL3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex.
  • 基因功能參考文獻：
    1. data indicate an oncogenic role of miR-181d in CRC by promoting glycolysis, and miR-181d/CRY2/FBXL3/c-myc feedback loop might be a therapeutic target for patients with CRC. PMID: 28749470
    2. These results demonstrate that CRY2 stability controlled by FBXL3 plays a key role in the regulation of human sleep wake behavior. PMID: 27529127
    3. CRY2 and FBXL3 cooperatively degrade c-MYC preventing the development of cancer. PMID: 27840026
    4. Data show that CRISPR/Cas9 genome editing generated F-box and leucine-rich repeat protein 3 (Fbxl3) knockout in circadian clock model U2OS cells. PMID: 26243628
    5. Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complex. PMID: 24085301
    6. Mutation in the Fbxl3 protein reveals distinct roles for CRY1 and CRY2 in the circadian molecular clockwork. PMID: 23616524
    7. crystal structures of mammalian CRY2 in its apo, FAD-bound and FBXL3-SKP1-complexed forms PMID: 23503662
    8. study demonstrates that the SCF(Fbxl3)ubiquitin ligase controls the oscillations of the circadian clock by mediating the degradation of Cry1 and Cry2 proteins PMID: 17463251

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Predominantly nuclear.
  • 組織特異性：
    Widely expressed.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13599

    OMIM: 605653

    KEGG: hsa:26224

    STRING: 9606.ENSP00000347834

    UniGene: Hs.508284