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  4. Phospho-PPP1R2 (Ser120/Ser121) Antibody

Phospho-PPP1R2 (Ser120/Ser121) Antibody

  • 中文名稱：
    磷酸化-PPP1R2 (Ser120/Ser121)兔多克隆抗體
  • 貨號：
    CSB-PA960014
  • 規(guī)格：
    ￥2454
  • 圖片：
    • Immunohistochemistry analysis of paraffin-embedded human heart tissue using PPP1R2 (Phospho-Ser120+Ser121) antibody. The picture on the right is treated with the synthesized peptide.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) PPP1R2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    PPP1R2
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Peptide sequence around phosphorylation site of serine 120 and serine 121 (Q-E-S(p)-S(p)-GE) derived from Human PPP1R2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibitor of protein-phosphatase 1.
  • 基因功能參考文獻：
    1. The results show that contrary to initial observations PPP1R2-related pseudogenes are not simple bystanders of the evolutionary process but may rather be at the origin of genes with novel functions. PMID: 24195737
    2. The potential phosphosites in PPP1R2 are substituted by non-phosphorylable residues, T73P and S87R, in PPP1R2P3. PMID: 23506001
    3. Pin1 and phosphatase inhibitor-2 are conserved among eukaryotes from yeast to humans and make an ancient partnership that provides a means for regulating Pin1 specificity and function. PMID: 21714498
    4. Inh2 can enhance the kinase activity of the Nek2.PP1C complex via inhibition of phosphatase activity to initiate centrosome separation PMID: 12221103
    5. first demonstration that glycogen synthase kinase-3beta associates with PP1C/I-2 complex and phosphorylates I-2 at T72 in intact cells PMID: 12761178
    6. These results indicate that the protein phosphatase-1/inhibitor-2 complex differentially regulates GSK3 dephosphorylation induced by KCl and that GSK3 activity regulates SERCA2 levels. PMID: 16987514
    7. Results suggest that phosphatase inhibitor 2 localizes to the primary cilium of human retinal epithelial cells where it affects both Ser/Thr phosphorylation and is required for full tubulin acetylation. PMID: 19036150
    8. Studies in hamster indicate that modulation of type 1 protein phosphatase (PP1) activity by inhibitor-2 (INH-2) provides a potential new treatment for heart failure without activating protein kinase A (PKA) signaling. PMID: 16627625

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  • 蛋白家族：
    Protein phosphatase inhibitor 2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9288

    OMIM: 601792

    KEGG: hsa:5504

    STRING: 9606.ENSP00000328178

    UniGene: Hs.535731