RAB6B Antibody

說明書

產品詳情

Uniprot No.：

Q9NRW1
基因名：

RAB6B
別名：

9630015C03 antibody; AI844641 antibody; C330006L04Rik antibody; D9Bwg0185e antibody; OTTHUMP00000216372 antibody; RAB6B antibody; RAB6B member RAS oncogene family antibody; RAB6B_HUMAN antibody; Ras related protein Rab 6B antibody; Ras-related protein Rab-6B antibody; Small GTP binding protein antibody; Small GTPase RAB6B antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human RAB6B
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.
基因功能參考文獻：
1. Conformational changes in human neuronal Rab6B between its inactive GDP and active GTP-like state are observed mainly in the switch I and switch II regions, confirming their role as a molecular switch. PMID: 16790928
2. The brain-specific Rab6B via Bicaudal-D1 is linked to the dynein/dynactin complex, suggesting a regulatory role for Rab6B in the retrograde transport of cargo in neuronal cells. PMID: 17707369
3. DYNLRB1 specifically interacts with all three Rab6 isoforms and co-localises at the Golgi. PMID: 18044744
亞細胞定位：

Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment. Cytoplasmic vesicle.
蛋白家族：

Small GTPase superfamily, Rab family
組織特異性：

Predominantly expressed in brain.
數(shù)據庫鏈接：

HGNC: 14902

OMIM: 615852

KEGG: hsa:51560

STRING: 9606.ENSP00000285208

UniGene: Hs.715344