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  4. RAD54B Antibody, FITC conjugated

RAD54B Antibody, FITC conjugated

  • 中文名稱(chēng)：
    RAD54B兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA896748LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) RAD54B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RAD54B
  • 別名：
    RAD54B antibody; DNA repair and recombination protein RAD54B antibody; EC 3.6.4.- antibody; RAD54 homolog B antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DNA repair and recombination protein RAD54B protein (1-167AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group.
  • 基因功能參考文獻(xiàn)：
    1. High RAD54B expression is associated with hepatoma. PMID: 29956808
    2. Review of structural aspects of RAD54B, molecular functions associated with its cellular roles in preventing genome instability, and how aberrant function contributes to oncogenesis. PMID: 28295846
    3. RAD54B expression has potential to serve as a novel prognostic biomarker, particularly for distant recurrence in colorectal cancer PMID: 26046797
    4. Patients with expression of both FEN1 and RAD54B were prone to have advanced nodal involvement and significantly poor prognosis. PMID: 26431531
    5. The scaffolding function of Rad54B dynamically regulates the maintenance of genome integrity by limiting checkpoint strength. PMID: 25384516
    6. support a model in which RAD54L and RAD54B counteract genome-destabilizing effects of direct binding of RAD51 to dsDNA in tumor cells PMID: 25765654
    7. RAD54B-deficient cells are selectively killed relative to controls via siRNA-based silencing of SOD1 PMID: 24002644
    8. RAD54B and GREB1 gene polymorphisms may not be associated with PCOS in the Han Chinese population. PMID: 23876972
    9. These results suggest that hINO80 assists double-strand break repair by positively regulating the expression of the Rad54B and XRCC3 genes. PMID: 20687897
    10. Rad54B is a DNA-dependent ATPase and has biochemical properties different from its structural homolog in yeast, Tid1/Rdh54 PMID: 11884632
    11. Rad54B enhanced the DNA strand-exchange activity of Dmc1 by stabilizing the Dmc1-single-stranded DNA complex. PMID: 16945962
    12. the loss of heterozygosity (LOH) in the 8q12-q24.1 chromosomal region, containing RAD54B gene isn't predictive for breast cancer PMID: 17585536
    13. S100A11 targets Rad54B to sites of DNA DSB repair sites and has a role in p21-based regulation of cell cycle PMID: 18463164
    14. RAD54B binding may affect the quaternary structure of DMC1. PMID: 18718930
    15. RAD54B-deficient human colorectal cancer cells are sensitive to synthetic lethal killing by reduced FEN1 expression, while isogenic RAD54B proficient cells are not PMID: 19218431

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family
  • 組織特異性：
    Abundantly expressed in testis and spleen. Relatively low levels observed in thymus, prostate, ovary and colon.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17228

    OMIM: 604289

    KEGG: hsa:25788

    STRING: 9606.ENSP00000336606

    UniGene: Hs.30561