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RASA3 Antibody

  • 中文名稱：
    RASA3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA002639
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using GAP1-InsP4 BP Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    GAP III antibody; GAP1(IP4BP) antibody; GAP1IP4BP antibody; GAPIII antibody; GTPase activating protein 1 family antibody; GTPase activating protein III antibody; Inositol 1 3 4 5 tetrakisphosphate binding protein antibody; Inositol 1345 tetrakisphosphate binding protein antibody; Ins P4 binding protein antibody; Ins P4-binding protein antibody; Ins(1 3 4 5)P4 binding protein antibody; Ins(1345)P4 binding protein antibody; MGC46517 antibody; MGC47588 antibody; Ras GTPase activating protein 3 antibody; Ras GTPase-activating protein 3 antibody; RAS p21 protein activator 3 antibody; RASA 3 antibody; RASA3 antibody; RASA3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human GAP1-InsP4 BP.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
  • 基因功能參考文獻(xiàn)：
    1. Rasa3 is a critical regulator of Rap1 in endothelial cells which controls adhesions properties and vascular lumen integrity; its specific endothelial cell inactivation results in occluded blood vessels, hemorrhages and early embryonic death in mouse, mimicking thus the Rasa3-/- mouse phenotype. PMID: 29381707
    2. these results support an important role for Rasa3 in PI3K-dependent integrin alphaIIbbeta3-mediated outside-in signaling and cell spreading. PMID: 27903653
    3. the function of RASA3 during megakaryopoiesis, megakaryocyte adhesion and migration as well as integrin signaling has been reported. PMID: 25294679
    4. role in intracellular calcium homeostasis PMID: 12356770
    5. model in which the Ras GAP-related domain of GAP1(IP4BP) functions to stabilize the switch II region of Rap1, allowing stabilization of the transition state during GTP hydrolysis initiated by the arginine finger PMID: 19433443
    6. GAP1IP4BP is an inositol 1,3,4,5-tetrakisphosphate regulated plasma membrane associated Ras and Rap GAP. Membrane association results from its PH domain binding phosphatidylinositol 4,5-bisphosphate. PMID: 7637787

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  • 亞細(xì)胞定位：
    Cell membrane.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20331

    OMIM: 605182

    KEGG: hsa:22821

    STRING: 9606.ENSP00000335029

    UniGene: Hs.593075