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RBM45 Antibody, Biotin conjugated

  • 中文名稱：
    RBM45兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA814203LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RBM45 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RBM45
  • 別名：
    Developmentally-regulated RNA-binding protein 1 antibody; DRB1 antibody; FLJ44612 antibody; MGC42237 antibody; Putative RNA binding protein RB 1 antibody; RB-1 antibody; RBM45 antibody; RBM45_HUMAN antibody; RNA-binding motif protein 45 antibody; RNA-binding protein 45 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human RNA-binding protein 45 protein (170-244AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    RNA-binding protein with binding specificity for poly(C). May play an important role in neural development.
  • 基因功能參考文獻(xiàn)：
    1. Results suggest that RBM45 serves as a negative regulator to prevent FUS-mediated excessive recruitment of HDAC1 to the sites of DNA damage. PMID: 29140459
    2. Analysis of the biological processes and pathways associated with RBM45-interacting proteins indicates enrichment for nuclear RNA processing/splicing via association with hnRNP proteins and cytoplasmic RNA translation via eiF2 and eiF4 pathways. PMID: 26979993
    3. using an in vitro cellular model, we demonstrated that Drb1 co-localizes with cytoplasmic aggregates mediated by TAR DNA-binding protein 43 PMID: 27226551
    4. RMB45 may function as a homo-oligomer and that its oligomerization contributes to ALS/FTLD RNA-binding protein aggregation. PMID: 26391765
    5. Data indicate that RNA binding protein RBM45/Kelch-like ECH-associated protein 1 (KEAP1) interactions in amyotrophic lateral sclerosis (ALS) spinal cord. PMID: 25939382
    6. This study demonistrated that RBM45 protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients. PMID: 22993125
    7. a new member of RRM-type neural RNA-binding protein PMID: 12220514

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  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. May shuttle between cytoplasm and nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24468

    OMIM: 608888

    KEGG: hsa:129831

    STRING: 9606.ENSP00000286070

    UniGene: Hs.377257