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  4. RBP3 Antibody, FITC conjugated

RBP3 Antibody, FITC conjugated

  • 中文名稱：
    RBP3兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA019482LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RBP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RBP3
  • 別名：
    D10S64 antibody; D10S65 antibody; D10S66 antibody; Interphotoreceptor retinoid binding protein antibody; Interphotoreceptor retinoid-binding protein antibody; Interstitial retinol binding protein antibody; Interstitial retinol-binding protein antibody; IRBP antibody; RBP 3 antibody; rbp3 antibody; RBPI antibody; RET3_HUMAN antibody; Retinol binding protein 3 antibody; Retinol binding protein 3 interstitial antibody; Retinol-binding protein 3 antibody; RP66 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Retinol-binding protein 3 protein (1146-1246AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
  • 基因功能參考文獻：
    1. this report is the first to describe the retinal dystrophy in children caused by homozygous nonsense RBP3 mutations, highlighting the requirement for IRBP in normal eye development and visual function. PMID: 25766589
    2. CMPK1 and RBP3 are associated with corneal curvature in Asian populations. PMID: 24963161
    3. We found that most patients with macular telangiectasia-2 possess retinal autoantibodies, the most prevalent of which were directed against AGL, RBP3, and CK-B. PMID: 23882694
    4. Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). PMID: 23486466
    5. The mouse retina promotes cone dark adaptation eightfold faster than the retinal pigment epithelium. However, complete cone recovery requires both visual cycles. PMID: 21613504
    6. Underproduction of IRBP is an early event in the human diabetic retina and is associated with retinal neurodegeneration. PMID: 19823802
    7. studies suggest that IRBP and S-Ag can initiate innate and, in sensitive individuals, adaptive immune response by attracting iDCs and T and B cells expressing CXCR3 and CXCR5 PMID: 15713799
    8. analysis of IRBP proteolysis is useful as a biomarker for uveitis PMID: 18266969
    9. Mutations in RBP3 are an infrequent cause of autosomal recessive retinitis pigmentosa. PMID: 19074801
    10. In interphotoreceptor retinoid-binding protein transgenic mice cone dysfunction appears to be caused by abnormal trafficking of cone opsins due to impaired delivery of all-transretinaldehyde chromophore without IRBP. PMID: 19193895

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  • 相關(guān)疾?。?/div>
    Retinitis pigmentosa 66 (RP66)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.
  • 蛋白家族：
    Peptidase S41A family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9921

    OMIM: 180290

    KEGG: hsa:5949

    STRING: 9606.ENSP00000224600

    UniGene: Hs.591928