RFX2 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

P48378
基因名：

RFX2
別名：

DNA-binding protein RFX2 antibody; HLA class II regulatory factor RFX2 antibody; regulatory factor X 2 (influences HLA class II expression) antibody; Regulatory factor X 2 antibody; regulatory factor X2 antibody; RFX2 antibody; RFX2_HUMAN antibody; trans acting regulatory factor 2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Synthesized peptide derived from the C-terminal region of Human RFX2.
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

IHC, ELISA

推薦稀釋比：

Application	Recommended Dilution
IHC	1:100-1:300
ELISA	1:10000

Protocols：

Immunohistochemistry (IHC) Protocol
ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6.
基因功能參考文獻(xiàn)：
1. Rfx2 coordinates multiple, distinct gene expression programs in multi-ciliated epithelial cells, regulating genes that control cell movement, ciliogenesis, and cilia function. PMID: 24424412
2. We show binding of RFX proteins to an evolutionarily conserved X-box in the ALMS1 proximal promoter and present evidence that these proteins are responsible for ALMS1 transcription during growth arrest PMID: 20381594
3. novel role for the RFX family of transcription factors as modulators of Ras signalling in epithelial cells. PMID: 15024578
亞細(xì)胞定位：

Nucleus. Cytoplasm.
蛋白家族：

RFX family
數(shù)據(jù)庫鏈接：

HGNC: 9983

OMIM: 142765

KEGG: hsa:5990

STRING: 9606.ENSP00000306335

UniGene: Hs.465709