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RGS19 Antibody, FITC conjugated

  • 中文名稱：
    RGS19兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào)：
    CSB-PA019650LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RGS19 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RGS19
  • 別名：
    G alpha interacting protein antibody; G protein signalling regulator 19 antibody; G protein; alpha-interacting protein antibody; G-alpha-interacting protein antibody; GAIP antibody; GNAI3IP antibody; Guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein antibody; Regulator of G protein signalling 19 antibody; Regulator of G-protein signaling 19 antibody; RGS19 antibody; RGS19_HUMAN antibody; RGSGAIP antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
  • 基因功能參考文獻(xiàn)：
    1. RGS19 senses cellular iron availability and is stabilized under iron-depleted conditions, resulting in the induction of a growth-inhibitory signal. PMID: 26116529
    2. RGS19 may play an important role in controlling the degree of synergism between FGF-1 receptors and 5-HT1A receptors, that may work together to mediate an anti-depressant effect. PMID: 24793302
    3. Overall methylation levels in the promoter regions of three genes (ALDH1A1, OPRL1 and RGS19) are elevated in subjects who were exposed to childhood adversity. PMID: 23799031
    4. The RGS19 inhibits Ras signaling through a complex network involving a scaffold protein KSR1 and a nucleoside diphosphate kinase Nm23. PMID: 23416464
    5. elevated expression of RGS19 can severely disrupt the regulation of mitogen-activated protein kinases by small GTPases PMID: 22045062
    6. cyclin D1/3 and Cdk6 were upregulated in HEK293 cells overexpressing RGS19, while INK4A and INK4B were reduced PMID: 21705135
    7. gene structure and transcription regulation PMID: 12507475
    8. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling PMID: 15356268

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  • 亞細(xì)胞定位：
    Membrane; Lipid-anchor.
  • 組織特異性：
    Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13735

    OMIM: 605071

    KEGG: hsa:10287

    STRING: 9606.ENSP00000333194

    UniGene: Hs.422336