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  4. RGS20 Antibody

RGS20 Antibody

  • 中文名稱：
    RGS20兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019652ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: RGS20 antibody at 8μg/ml + Mouse brain tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44, 32, 22, 18, 26, 28 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA019652ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA019652ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RGS20 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RGS20
  • 別名：
    G(z)GAP antibody; Gz selective GTPase activating protein antibody; Gz-GAP antibody; Gz-selective GTPase-activating protein antibody; HGNC:14600 antibody; Regulator of G protein signaling 20 antibody; Regulator of G-protein signaling 20 antibody; Regulator of G-protein signaling Z1 antibody; Regulator of Gz selective protein signaling 1 antibody; Regulator of Gz-selective protein signaling 1 antibody; RGS20 antibody; RGS20_HUMAN antibody; RGSZ1 antibody; ZGAP1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Regulator of G-protein signaling 20 protein (1-241AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G-protein. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins.
  • 基因功能參考文獻(xiàn)：
    1. NEAT1 silencing also inhibited tumor growth in vivo. Collectively, we revealed that the NEAT1/miR365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment. PMID: 29484420
    2. Data suggest that Gpr176 (G-protein coupled receptor 176) is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176. [REVIEW] PMID: 28502923
    3. These results suggest that the expression of RGS20 may promote metastasis of tumor cells. PMID: 27495875
    4. Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC). PMID: 28237701
    5. provide new evidence that RGSZ1 interacts not only with Galpha(z,) but also with Galpha(i), as supported by in vitro binding assays and functional studies PMID: 12379657
    6. NMR study PMID: 14872136
    7. The major function of PKCI-1 is to modulate mu opioid receptor signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction. PMID: 17126529

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  • 亞細(xì)胞定位：
    Membrane; Lipid-anchor. Nucleus. Cytoplasm.
  • 組織特異性：
    Isoform 5 is expressed in brain at high levels in the caudate nucleus and temporal lobe.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14600

    OMIM: 607193

    KEGG: hsa:8601

    STRING: 9606.ENSP00000297313

    UniGene: Hs.368733