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  4. RHBDL2 Antibody, FITC conjugated

RHBDL2 Antibody, FITC conjugated

  • 中文名稱：
    RHBDL2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA019672LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RHBDL2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RHBDL2
  • 別名：
    RHBDL2 antibody; Rhomboid-related protein 2 antibody; RRP2 antibody; EC 3.4.21.105 antibody; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2 antibody; N-terminal fragment antibody; NTF); Rhomboid-related protein 2 antibody; C-terminal fragment antibody; CTF)] antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Rhomboid-related protein 2 protein (12-132AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.
  • 基因功能參考文獻：
    1. Thrombomodulin and RHBDL2 are upregulated in human HaCaT cells stimulated by scratch wounds; furthermore, increased solulbe thrombomodulin was found in culture medium. PMID: 21833011
    2. RHBDL2 cleaves epidermal growth factor just outside its transmembrane domain, thereby facilitating its secretion and triggering activation of the epidermal growth factor receptor. PMID: 21494248
    3. Substrate specificity of RHBDL2 intramembrane protease is governed by helix-breaking residues in the transmembrane domain. PMID: 12820957
    4. Here, the authors show that RHBDL2 is produced as a proenzyme and that the processing of RHBDL2 is required for its cellular protease activity. PMID: 19850051
    5. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. PMID: 15047175

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  • 亞細胞定位：
    [Rhomboid-related protein 2, C-terminal fragment]: Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Peptidase S54 family
  • 數(shù)據庫鏈接：

    HGNC: 16083

    OMIM: 608962

    KEGG: hsa:54933

    STRING: 9606.ENSP00000289248

    UniGene: Hs.524626