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RINT1 Antibody, Biotin conjugated

  • 中文名稱：
    RINT1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA747351LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RINT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RINT1
  • 別名：
    DKFZp667H2324 antibody; FLJ11785 antibody; HsRINT 1 antibody; HsRINT-1 antibody; HsRINT1 antibody; RAD50 interacting protein 1 antibody; RAD50 interactor 1 antibody; RAD50-interacting protein 1 antibody; RINT 1 antibody; RINT-1 antibody; RINT1 antibody; RINT1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human RAD50-interacting protein 1 protein (401-700AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.
  • 基因功能參考文獻(xiàn)：
    1. Study presents evidence that in the Caucasian population, RINT1 does not represent a moderate- penetrance breast cancer susceptibility gene, and find no evidence to support an association of RINT1 mutation with Lynch syndrome-related cancer incidence in breast cancer families. PMID: 27544226
    2. these data are more consistent with the hypothesis that RINT1 functions as an oncogene rather than a tumor suppressor gene in the context of colorectal cancer. PMID: 28264000
    3. HPV E2 protein targets Rad50-interacting protein 1 (Rint1) to facilitate virus genome replication. PMID: 28031358
    4. RINT-1 interacts with MSP58 and UBF within nucleoli and plays a role in ribosomal gene transcription. PMID: 27530925
    5. Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures. PMID: 25304616
    6. Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome. PMID: 25050558
    7. RINT-1 is also required for endosome-to-trans-Golgi network trafficking. PMID: 23885118
    8. RINT1 was validated as a novel glioblastoma oncogene PMID: 23074196
    9. These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division. PMID: 17470549
    10. Rab6 regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10/RINT-1 and COG. PMID: 17699596

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  • 亞細(xì)胞定位：
    Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein.
  • 蛋白家族：
    RINT1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 21876

    OMIM: 610089

    KEGG: hsa:60561

    STRING: 9606.ENSP00000257700

    UniGene: Hs.531388