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RLIM Antibody

  • 中文名稱：
    RLIM兔多克隆抗體
  • 貨號(hào)：
    CSB-PA019748GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    RLIM
  • 別名：
    E3 ubiquitin-protein ligase RLIM antibody; LIM domain-interacting RING finger protein antibody; R-LIM antibody; Renal carcinoma antigen NY-REN-43 antibody; RING finger LIM domain-binding protein antibody; RING finger protein 12 antibody; RLIM antibody; RNF12 antibody; RNF12_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human RLIM
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
  • 基因功能參考文獻(xiàn)：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that RLIM is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. missense mutation in RLIM gene was identified in four males with intellectual disability from a three-generation family. PMID: 25735484
    3. RNF12 is a novel positive regulator of p53 pathway and an external E3 ubiquitin ligase for MDM2 destruction. PMID: 26926424
    4. Rlim is a novel regulator of Stathmin protein in a ubiquitin-dependent manner, and represents a new pathway for malignant phenotype turnover by modulating the level of Stathmin protein in human osteosarcomas. PMID: 24686088
    5. hus regulated nucleocytoplasmic shuttling of RLIM/Rnf12 coordinates cellular compartments during mammary alveolar cell survival PMID: 23904271
    6. TP53 does not directly bind to the RLIM promoter, it physically interacts with and prevents the binding of Sp1 to the RLIM promoter. PMID: 23650532
    7. these results indicated that RLIM is an important positive regulator in TGF-beta signaling pathway and cell migration. PMID: 21945933
    8. RLIM represents a new pathway for telomere maintenance by modulating the level of TRF1 at telomeres. PMID: 19164295
    9. These findings provide evidence for a dose-dependent role of RNF12 in the XCI counting and initiation process. PMID: 19945382
    10. Functional analysis of the Xenopus homolog PMID: 12874135

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  • 相關(guān)疾?。?/div>
    Mental retardation, X-linked 61 (MRX61)
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    RNF12 family
  • 組織特異性：
    Expressed in many tissues.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13429

    OMIM: 300379

    KEGG: hsa:51132

    STRING: 9606.ENSP00000253571

    UniGene: Hs.653288