RPAIN Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q86UA6
基因名：

RPAIN
別名：

2400006N03Rik antibody; DN-393H17.1 antibody; FLJ25625 antibody; FLJ30490 antibody; FLJ42429 antibody; HRIP antibody; MGC4189 antibody; Nuclear transporter antibody; RAP interaction protein antibody; RIP antibody; RIP_HUMAN antibody; RP23 83I13.5 antibody; RPA interacting protein antibody; RPA-interacting protein antibody; Rpain antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Human RPAIN
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.
基因功能參考文獻：
1. Suggest that increased RPAIN levels may contribute to the development of preeclampsia through regulating trophoblast invasion and apoptosis via C1q. PMID: 28032589
2. hRIPalpha is involved in cell proliferation through regulation of RPA transport PMID: 23010595
3. The results show that DDX3, eIF5A, and hRIP enhance HIV-1 internal ribosomal entry site-mediated translation. PMID: 21360055
4. hRIPbeta localises to the PML nuclear body and transports replication protein A (PML) into the PML nuclear body and releases RPA upon UV irradiation. PMID: 16135809
亞細胞定位：

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body.
組織特異性：

Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
數(shù)據(jù)庫鏈接：

HGNC: 28641

OMIM: 617299

KEGG: hsa:84268

STRING: 9606.ENSP00000385814

UniGene: Hs.462086