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SCAF4 Antibody

  • 中文名稱：
    SCAF4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA040070
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO cells using SFRS15 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SCAF4
  • 別名：
    SCAF4 antibody; KIAA1172 antibody; SFRS15 antibody; SR-related and CTD-associated factor 4 antibody; CTD-binding SR-like protein RA4 antibody; Splicing factor antibody; arginine/serine-rich 15 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human SFRS15.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough.
  • 基因功能參考文獻(xiàn)：
    1. Report frequency of SFRS15 SNPs in diabetic nephropathy. PMID: 24821155
    2. Describes function of the CTD-interacting domain of human SCAF8, human SCAF4, and similar proteins in S. cerevisiae. PMID: 18550522
    3. Describes identification of rat serine/arginine-rich splicing factors that interact with RNA polymerase II, including rA1, rA4, rA8, and rA9. PMID: 8692929
  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Splicing factor SR family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 19304

    OMIM: 616023

    KEGG: hsa:57466

    STRING: 9606.ENSP00000286835

    UniGene: Hs.17255