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SDCCAG8 Antibody

  • 中文名稱：
    SDCCAG8兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006722
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SDCCAG8
  • 別名：
    Antigen NY CO 8 antibody; Antigen NY-CO-8 antibody; BBS16 antibody; CCCAP antibody; CCCAP SLSN7 antibody; Centrosomal colon cancer autoantigen protein antibody; hCCCAP antibody; HSPC085 antibody; NPHP10 antibody; NPHP10 gene antibody; NY-CO-8 antibody; Sdccag8 antibody; SDCG8_HUMAN antibody; Serologically defined colon cancer antigen 8 antibody; Serologically defined colon cancer antigen 8 homolog antibody; SLSN7 antibody; SLSN7 gene antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human NY-CO-8.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in the establishment of cell polarity and epithelial lumen formation. Plays also an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis.
  • 基因功能參考文獻(xiàn)：
    1. Variants in NPHS2, SDCCAG8 and near BMP4 appear to interact with APOL1 to modulate the risk for non-diabetic end stage kidney disease in african americans. PMID: 24157943
    2. significant associations in schizophrenia to SDCAAG8 and extensive replication of associations reported by the Schizophrenia. PMID: 22614287
    3. Our results and prior literature suggest that SDCCAG8 could play an important role in presumed Bardet-Biedl syndrome (BBS) patients affected with severe kidney disease and absent polydactyly. PMID: 22626039
    4. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement. PMID: 22095114
    5. Mutation of SDCCAG8 is associated with retinal-renal ciliopathy. PMID: 20835237

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  • 相關(guān)疾病：
    Senior-Loken syndrome 7 (SLSN7); Bardet-Biedl syndrome 16 (BBS16)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body. Cell junction. Note=Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle.; [Isoform 2]: Cytoplasm.
  • 組織特異性：
    Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10671

    OMIM: 613524

    KEGG: hsa:10806

    STRING: 9606.ENSP00000355499

    UniGene: Hs.591530