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SENP5 Antibody

  • 中文名稱：
    SENP5兔多克隆抗體
  • 貨號：
    CSB-PA911693
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COS7 cells, using SENP5 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using SENP5 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SENP5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SENP5
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from Internal of Human SENP5.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.
  • 基因功能參考文獻：
    1. Results from a study on gene expression variability markers in early-stage human embryos shows that SENP5 is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
    2. Mild oxidative stress stabilized the SENP5 protein in the oral squamous cell carcinoma cells, and only the combination of SENP5 silencing and H2O2 application led to mitochondria fragmentation and a significant increase in cell apoptosis. PMID: 25901414
    3. Low expression of SENP5 is associated with good prognosis among breast cancer patients. PMID: 24658161
    4. Knockdown of SENP5 resulted in increased levels of SUMO-1 and SUMO-2/3, inhibition of cell proliferation, defects in nuclear morphology, and appearance of binucleate cells, revealing an essential role for SENP5 in mitosis and/or cytokinesis. PMID: 16738315
    5. altered subcellular localization of SENP5 in oral squamous cell carcinoma (OSCC) cells and the correlation between SENP5 expression and the differentiation of OSCC. PMID: 18949399
    6. Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases. PMID: 19015314

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  • 亞細胞定位：
    Nucleus, nucleolus.
  • 蛋白家族：
    Peptidase C48 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28407

    OMIM: 612845

    KEGG: hsa:205564

    STRING: 9606.ENSP00000327197

    UniGene: Hs.240770