SF3B3 Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q15393
基因名：

SF3B3
別名：

KIAA0017 antibody; Pre mRNA splicing factor SF3b 130 kDa subunit antibody; Pre-mRNA-splicing factor SF3b 130 kDa subunit antibody; RSE1 antibody; SAP 130 antibody; SAP130 antibody; SF3b130 antibody; SF3B3 antibody; SF3B3_HUMAN antibody; Spliceosome associated protein 130 antibody; Spliceosome-associated protein 130 antibody; Splicing factor 3b subunit 3 130kD antibody; Splicing factor 3B subunit 3 antibody; STAF130 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SF3B3
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex, a constituent of the spliceosome. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
基因功能參考文獻：
1. These results suggest SF3B3 as a key regulator of EZH2 pre-mRNA splicing and SF3B3 may represent a novel prognostic factor and potential therapeutic target in clear cell renal cell carcinoma PMID: 27879367
2. our findings suggest a role for the elevated expression of SF3B3 in poor prognosis and tamoxifen resistance, leading to recurrence of estrogen receptor-positive breast cancer PMID: 25431237
3. Report detection of SF3B3 gene mutations in oral cancer using high resolution melting analysis. PMID: 25651737
亞細胞定位：

Nucleus.
蛋白家族：

RSE1 family
數(shù)據(jù)庫鏈接：

HGNC: 10770

OMIM: 605592

KEGG: hsa:23450

STRING: 9606.ENSP00000305790

UniGene: Hs.514435