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SH2D4A Antibody

  • 中文名稱：
    SH2D4A兔多克隆抗體
  • 貨號：
    CSB-PA050002
  • 規(guī)格：
    ￥1090
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SH2D4A
  • 別名：
    FLJ20967 antibody; PPP1R38 antibody; Protein phosphatase 1 regulatory subunit 38 antibody; Protein SH antibody; Protein SH(2)A antibody; Protein SH2A antibody; SH2 domain containing 4A antibody; SH2 domain containing protein 4A antibody; SH2 domain-containing protein 4A antibody; SH24A_HUMAN antibody; SH2A antibody; Sh2d4a antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human SH2D4A.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
  • 基因功能參考文獻：
    1. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
    2. New evidence for SH2D4A involvement in hepatocellular carcinoma pathogenesis demonstrating for the first time its deregulation in cirrhotic nodules. PMID: 24315626
    3. SH2D4A is dispensable for TCR signal transduction in T cells PMID: 18641339
    4. SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway. PMID: 19712589
  • 亞細胞定位：
    Cytoplasm.
  • 組織特異性：
    Ubiquitously expressed. Aberrantly expressed in some cancers.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26102

    OMIM: 614968

    KEGG: hsa:63898

    STRING: 9606.ENSP00000265807

    UniGene: Hs.303208