SH2D4A Antibody

說明書

產(chǎn)品詳情

Uniprot No.：

Q9H788
基因名：

SH2D4A
別名：

FLJ20967 antibody; PPP1R38 antibody; Protein phosphatase 1 regulatory subunit 38 antibody; Protein SH antibody; Protein SH(2)A antibody; Protein SH2A antibody; SH2 domain containing 4A antibody; SH2 domain containing protein 4A antibody; SH2 domain-containing protein 4A antibody; SH24A_HUMAN antibody; SH2A antibody; Sh2d4a antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Human SH2D4A
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
基因功能參考文獻(xiàn)：
1. The chromosome 8p tumor suppressor genes SORBS3 and SH2D4A are physically and functionally linked and provide a molecular mechanism of inhibiting STAT3-mediated IL-6 signaling in hepatocellular carcinoma cells. PMID: 27311882
2. New evidence for SH2D4A involvement in hepatocellular carcinoma pathogenesis demonstrating for the first time its deregulation in cirrhotic nodules. PMID: 24315626
3. SH2D4A is dispensable for TCR signal transduction in T cells PMID: 18641339
4. SH2D4A inhibited cell proliferation by suppression of the ERalpha/PLC-gamma/PKC signaling pathway. PMID: 19712589
亞細(xì)胞定位：

Cytoplasm.
組織特異性：

Ubiquitously expressed. Aberrantly expressed in some cancers.
數(shù)據(jù)庫鏈接：

HGNC: 26102

OMIM: 614968

KEGG: hsa:63898

STRING: 9606.ENSP00000265807

UniGene: Hs.303208