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SHPK Antibody

  • 中文名稱：
    SHPK兔多克隆抗體
  • 貨號：
    CSB-PA833951
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells, using CARKL antibody.
    • Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using CARKL antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SHPK Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SHPK
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human CARKL.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as a modulator of macrophage activation through control of glucose metabolism.
  • 基因功能參考文獻：
    1. CARKL-dependent metabolic reprogramming is required for proper M1- and M2-like macrophage polarization PMID: 22682222
    2. the CARKL-encoded protein, sedoheptulokinase (SHK), is responsible for the reaction: sedoheptulose + ATP --> sedoheptulose-7-phosphate + ADP, and deletion of CARKL causes urinary accumulation of sedoheptulose and erythritol PMID: 18186520
  • 相關(guān)疾?。?/div>
    Sedoheptulokinase deficiency (SHPKD)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    FGGY kinase family
  • 組織特異性：
    Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1492

    OMIM: 605060

    KEGG: hsa:23729

    STRING: 9606.ENSP00000225519

    UniGene: Hs.579217