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SIRPG Antibody

  • 中文名稱：
    SIRPG兔多克隆抗體
  • 貨號：
    CSB-PA021338GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    gen like family member B antibody; bA77C3.1 antibody; CD172 antigen-like family member B antibody; CD172g antibody; CD172g antigen antibody; FLJ42230 antibody; RP11-77C3.2 antibody; Signal regulatory protein beta 2 antibody; Signal regulatory protein gamma antibody; Signal-regulatory protein beta-2 antibody; Signal-regulatory protein gamma antibody; SIRP B2 antibody; SIRP beta 2 antibody; SIRP gamma antibody; SIRP-b2 antibody; SIRP-beta-2 antibody; SIRP-gamma antibody; SIRPB2 antibody; SIRPG antibody; SIRPG_HUMAN antibody; SIRPgamma antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human SIRPG
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
  • 基因功能參考文獻：
    1. SIRPgamma in complex with FabOX117 forms a dimer in the crystal. Binding to the Fab fixes the position of domain 1 relative to domains 2/3 exposing a surface which favours formation of a homotypic dimer. PMID: 23826770
    2. The independent non-obstructive azoospermia risk alleles are driven by variants in the protein-coding sequence of the two genes, SIRPA and SIRPG. PMID: 24162948
    3. a novel member of the signal regulatory protein (SIRP) family- with unique characteristics from both alpha and beta genes- termed SIRPgamma PMID: 15294972
    4. CD47 is enriched at endothelial junctions, and its interaction with SIRPgamma is required for human T-cell transendothelial migration PMID: 18524990
    5. tumor necrosis factor receptor superfamily, member 14 (TNFRSF14) and signal regulatory protein, gamma (SIRPG) appear to contribute to gender difference in incidence of systemic lupus erythematosus. PMID: 19473566

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15757

    OMIM: 605466

    KEGG: hsa:55423

    STRING: 9606.ENSP00000305529

    UniGene: Hs.590883