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SLC12A7 Antibody, HRP conjugated

  • 中文名稱：
    SLC12A7兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA893907LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC12A7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC12A7
  • 別名：
    D13Ertd261e antibody; Electroneutral potassium-chloride cotransporter 4 antibody; Furosemide sensitive KCl cotransporter 4 antibody; K Cl cotransporter KCC4 antibody; K-Cl cotransporter 4 antibody; Potassium/chloride transporter KCC4 antibody; S12A7_HUMAN antibody; SLC12A7 antibody; Solute carrier family 12 (potassium/chloride transporters), member 7 antibody; Solute carrier family 12 member 7 antibody; Solute carrier family 12, member 7 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 12 member 7 protein (11-117AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification.
  • 基因功能參考文獻：
    1. SLC12A7 gene amplification and overexpression occurs frequently in adrenocortical carcinoma and may play a role in adrenocortical carcinoma tumorigenesis. PMID: 26454676
    2. Negative stain transmission electron microscopy and single particle analysis of KCC4 and the aquaporin-1 AQP1 water channel, revealed the expected quaternary structures within homogeneous preparations, and thus correct protein folding and assembly. PMID: 21760919
    3. analysis of differences in large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4 PMID: 20516068
    4. KCC4 and H+,K+-ATPase are the main machineries for basal HCl secretion in the apical canalicular membrane of the resting parietal cell. They also may contribute in part to massive acid secretion in the stimulated state. PMID: 18984587
    5. In the metastatic cancer tissues, KCC4 colocalizes with IGF-I or EGF. PMID: 19887603
    6. Mice lacking SLC12A7 function suffer from deafness and renal metabolic acidosis. The phenotype suggests a function in inner ear potassium recycling. A function in the proton secreting alpha-intercalating cells of the kidney is shown. PMID: 11976689

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC12A transporter family
  • 組織特異性：
    Detected in muscle, brain, lung, heart and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10915

    OMIM: 604879

    KEGG: hsa:10723

    STRING: 9606.ENSP00000264930

    UniGene: Hs.172613