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SLC13A2 Antibody

  • 中文名稱：
    SLC13A2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA618762ESR2HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA618762ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618762ESR2HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC13A2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC13A2
  • 別名：
    SLC13A2 antibody; NADC1 antibody; SDCT1 antibody; Solute carrier family 13 member 2 antibody; Na(+)/dicarboxylate cotransporter 1 antibody; NaDC-1 antibody; Renal sodium/dicarboxylate cotransporter antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 13 member 2 protein (345-455AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cotransport of sodium ions and dicarboxylates such as succinate and citrate.
  • 基因功能參考文獻(xiàn)：
    1. Homozygous GG of rs11567842 SNP in NaDC-1 gene was a protective genotype for hypocitraturia in kidney stone patients PMID: 30155711
    2. Mapping Functionally Important Residues in the Na(+)/Dicarboxylate Cotransporter, NaDC1. PMID: 28731330
    3. NaDC1 is present throughout the entire proximal tubule, but was not detected in kidney tumors. PMID: 27927654
    4. cyclophilin isoform B is likely responsible for down-regulation of carrier expression by CsA and that it does so via its chaperone activity on NaDC1 (by direct interaction) rather than its rotamase activity. PMID: 21257749
    5. study concludes most of the naturally occurring nonsynonymous SNPs affect protein processing of NaDC1; several also affect functional properties; mutations are predicted to decrease transport activity PMID: 20610529
    6. This paper describes the cloning and functional characterization of the human Na(+)-coupled citrate transporter (NaCT). PMID: 12445824
    7. Data show that the sodium-dependent dicarboxylate co-transporter protein 1 is located in renal proximal tubule lumenal membranes, and that the C-terminal sequence is required for delivery and targeting and may contain the signal sequence. PMID: 15620109
    8. there are conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter PMID: 15774465
    9. B allele of I550V polymorphism of hNaDC-1 may be associated with a reduction in urinary citrate excretion and contribute to hypocitraturia in recurrent renal stone formers. PMID: 17470169
    10. The Ser or Thr at position 509 is the most important determinant of functional differences in apparent affinity for substrate and cations. The cation and substrate binding sites are located in close proximity to one another. PMID: 18161988

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  • 亞細(xì)胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC13A/DASS transporter (TC 2.A.47) family, NADC subfamily
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10917

    OMIM: 604148

    KEGG: hsa:9058

    UniGene: Hs.102307