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SLC24A4 Antibody

  • 中文名稱：
    SLC24A4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA006991
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAW264.7 cells using NCKX4 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SLC24A4
  • 別名：
    Na(+)/K(+)/Ca(2+)-exchange protein 4 antibody; NCKX4 antibody; NCKX4_HUMAN antibody; SHEP6 antibody; SLC24A2 antibody; SLC24A4 antibody; Sodium/potassium/calcium exchanger 4 antibody; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 4 antibody; Solute carrier family 24 member 4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human NCKX4.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.
  • 基因功能參考文獻(xiàn)：
    1. no significant relation was noted between SLC24A4 rs10498633 and late-onset Alzheimer;s disease risk in neither apolipoprotein E (APOE) epsilon4 carriers nor non-carriers after adjusting for age and gender PMID: 27215332
    2. pigment cells express robust, functional NCKX4 activity PMID: 27093457
    3. mutations in SLC24A4 and SLC24A5 are responsible for the phenotypic defects observed in human amylogenesis imperfecta and non-syndromic oculocutaneous albinism patients. PMID: 27129268
    4. The expressions of NCX1 and NCKX4 were significantly higher in the patent ductus arteriosus group at both the protein and mRNA levels. PMID: 25500693
    5. enamel maturation is dependent upon STIM1 and SLC24A4 function, and that there are important differences in the Ca(2+) transcellular transport systems used by secretory- and maturation-stage ameloblasts. PMID: 24621671
    6. Brain DNA methylation in sLC24A4 was associated with pathological Alzheimer disease. PMID: 25365775
    7. These findings support a key role for SLC24A4 in calcium transport during enamel formation. PMID: 23375655
    8. Taken together, these data demonstrate a potentially important role for NCX1 in control of Ca2+ homeostasis and link store depletion via STIM1 directly with NCX activation. PMID: 21126331
    9. identification and sequencing, as well as mapping to chromosomal region 14q32 PMID: 12379639
    10. IRF4 and SLC24A4 loci are associated with human hair color and skin pigmentation. PMID: 18483556

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  • 相關(guān)疾?。?/div>
    Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5)
  • 亞細(xì)胞定位：
    Cytoplasm. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily
  • 組織特異性：
    Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 10978

    OMIM: 210750

    KEGG: hsa:123041

    STRING: 9606.ENSP00000431840

    UniGene: Hs.385530