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SLC33A1 Antibody

  • 中文名稱：
    SLC33A1兔多克隆抗體
  • 貨號：
    CSB-PA291254
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA291254(SLC33A1 Antibody) at dilution 1/1100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SLC33A1
  • 別名：
    ACATN antibody; ACATN_HUMAN antibody; Acetyl CoA transporter antibody; Acetyl Coenzyme A transporter antibody; Acetyl coenzyme A transporter 1 antibody; Acetyl-CoA transporter 1 antibody; Acetyl-coenzyme A transporter 1 antibody; AT 1 antibody; AT-1 antibody; AT1 antibody; Human Angiotensin II Type 1 Receptor antibody; Slc33a1 antibody; Solute carrier family 33 (acetyl CoA transporter) member 1 antibody; Solute carrier family 33 member 1 antibody; spastic paraplegia 42 (autosomal dominant) antibody; SPG42 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human SLC33A1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides. Negatively regulates BMP signaling.
  • 基因功能參考文獻(xiàn)：
    1. results indicate that increased expression of AT-1 can cause an autistic-like phenotype by affecting key neuronal metabolic pathways. PMID: 27242167
    2. SLC33A1 can negatively regulate BMP signaling. PMID: 25402622
    3. Homozygosity mapping displayed a region of commonality among three families at chromosome 3q25. Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1. PMID: 22243965
    4. translocates acetyl-CoA into the ER lumen and is essential for cell viability PMID: 20826464
    5. A missense mutation in SLC33A1 causes autosomal-dominant spastic paraplegia. PMID: 19061983

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  • 相關(guān)疾病：
    Spastic paraplegia 42, autosomal dominant (SPG42); Congenital cataracts, hearing loss, and neurodegeneration (CCHLND)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    SLC33A transporter family
  • 組織特異性：
    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. With strongest signals in pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 95

    OMIM: 603690

    KEGG: hsa:9197

    STRING: 9606.ENSP00000352456

    UniGene: Hs.478031