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SLC37A4 Antibody

  • 中文名稱：
    SLC37A4兔多克隆抗體
  • 貨號(hào)：
    CSB-PA021613GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SLC37A4
  • 別名：
    G6PT1 antibody; G6PT1_HUMAN antibody; G6PT2 antibody; G6PT3 antibody; Glucose-5-phosphate transporter antibody; Glucose-6-phosphatase; transport (glucose) protein 3 antibody; Glucose-6-phosphatase; transport (glucose-6-phosphate) protein 1 antibody; Glucose-6-phosphatase; transport (phosphate/pyrophosphate) protein 2; antibody; Glucose-6-phosphate translocase antibody; Glucose-6-phosphate transporter 1 antibody; GSD1b antibody; GSD1c antibody; GSD1d antibody; MGC15729 antibody; Microsomal glucose-6-phosphate transporter antibody; PRO0685 antibody; SLC37A4 antibody; Solute carrier family 37 (glucose-6-phosphate transporter); member 4 antibody; Solute carrier family 37 member 4 antibody; Transformation-related gene 19 protein antibody; TRG-19 antibody; TRG19 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SLC37A4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrates that G6PT is essential for proliferation and differentiation of adipose-derived mesenchymal stem cells , providing important insights into the GSD-Ib phenotypes. PMID: 29238966
    2. We report the MFRP-related ocular phenotype in three siblings with glycogen storage disease type 1b. Molecular genetic studies identified novel mutations in the MFRP and SLC37A4 genes. PMID: 28511025
    3. The most common mutation of SLC37A4 genes identified in Korean patients was c.443C>T (p.Ala148Val), accounting for 55.6% (5/9 patients) of all GSD Ib patients and 38.9% of the tested alleles PMID: 28224773
    4. Data suggest that G6PT modulates autophagy independent of its transport activity; G6PT appears to up-regulate autophagy via inactivation of mTORC1; knockdown of G6PT expression activates mTORC1 (mechanistic target of rapamycin complex 1) activity. PMID: 25982172
    5. Five SLC37A4 gene mutations were detected in 7 (25%) of the 28 children PMID: 23965881
    6. A total of 11 SLC37A4 gene mutations were identified in 15 families of the mainland of China. The frequent mutations are p.Pro191Leu, p.Gly149Glu and c.870 + 5G > A. PMID: 21575371
    7. Two novel mutations were identified in these samples: one had a novel mutation (25C>T); the remaining sample carried a 49 bp deletion in intron 12. PMID: 21446359
    8. Our results suggest that in Sardinia, Glycogen storage disease Ib is caused by only one mutational event in the G6PT gene, further suggesting that Sardinia is a founder population. PMID: 20578944
    9. operates by a similar antiport mechanism as its E. coli homologue, namely, the substrate binds at the N- and C-terminal domain interface and is then transported across the membrane via a rocker-switch type of movement of the two domains PMID: 15260472
    10. mutational analysis of G6PT1 in type I glycogen storage disease PMID: 16435186
    11. Overexpression of recombinant glucose-6-phosphate translocase rescued the cells from curcumin-induced cell death [ glucose-6-phosphate translocase] PMID: 16777101
    12. A novel G6PT1 promoter polymorphism, 259C --> T was found; the - 259*T allele frequency was greater in term SIDS infants than in term control infants and preterm SIDS infants PMID: 17354259
    13. A molecular signaling axis regulates the invasive phenotype of brain tumor cells and highlights a new bioswitch function for glucose-6-phosphate transporter (G6PT) in cell survival. PMID: 17460777
    14. Targeted inhibition of either MT1-MMP or G6PT may lead to reduced infiltrative and invasive properties of brain tumor cells. PMID: 18267120
    15. Human G6PT contains 10-transmembrane helices and is more probable than the bacterial Uhp that contains 12-transmembrane helices. PMID: 19008136

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  • 相關(guān)疾?。?/div>
    Glycogen storage disease 1B (GSD1B); Glycogen storage disease 1C (GSD1C); Glycogen storage disease 1D (GSD1D)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Major facilitator superfamily, Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family
  • 組織特異性：
    Mostly expressed in liver and kidney.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4061

    OMIM: 232220

    KEGG: hsa:2542

    UniGene: Hs.719203