SMARCC2 Antibody
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中文名稱:SMARCC2兔多克隆抗體
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貨號:CSB-PA021807GA01HU
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規(guī)格:¥3,900
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其他:
產(chǎn)品詳情
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Uniprot No.:
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基因名:SMARCC2
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別名:BAF 170 antibody; BAF170 antibody; BRG1 associated factor 170 antibody; BRG1-associated factor 170 antibody; Chromatin remodeling complex BAF170 subunit antibody; CRACC 2 antibody; CRACC2 antibody; Mammalian chromatin remodeling complex BRG1 associated factor 170 antibody; Rsc 8 antibody; Rsc8 antibody; SMARCC 2 antibody; Smarcc2 antibody; SMRC2_HUMAN antibody; SWI/SNF complex 170 kDa subunit antibody; SWI/SNF complex subunit SMARCC2 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin c2 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 2 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2 antibody; SWI3 like protein antibody
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宿主:Rabbit
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反應(yīng)種屬:Human,Mouse,Rat
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免疫原:Human SMARCC2
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免疫原種屬:Homo sapiens (Human)
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抗體亞型:IgG
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純化方式:Antigen Affinity Purified
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
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產(chǎn)品提供形式:Liquid
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應(yīng)用范圍:ELISA,WB,IHC
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Protocols:
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儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途:For Research Use Only. Not for use in diagnostic or therapeutic procedures.
相關(guān)產(chǎn)品
靶點詳情
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功能:Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Can stimulate the ATPase activity of the catalytic subunit of these complexes. May be required for CoREST dependent repression of neuronal specific gene promoters in non-neuronal cells. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation.
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基因功能參考文獻:
- BAF170 is important for neurogenesis in embryonic olfactory epithelium. PMID: 27611684
- Identification of frameshift mutations in the SMARCC2 gene in gastric and colorectal cancers with microsatellite instability. PMID: 23030715
- study finds Baf53 and Baf170 are highly regulated in HIV-1-infected cells PMID: 21699904
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亞細胞定位:Nucleus.
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蛋白家族:SMARCC family
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組織特異性:Ubiquitously expressed.
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數(shù)據(jù)庫鏈接:
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