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SMC2 Antibody

  • 中文名稱：
    SMC2兔多克隆抗體
  • 貨號：
    CSB-PA014708
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Jurkat cells, A172 cells, A549 cells, Primary antibody: CSB-PA014708(SMC2 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SMC2
  • 別名：
    CAP E antibody; CAPE antibody; Chromosome associated protein E antibody; Chromosome-associated protein E antibody; FLJ10093 antibody; hCAP E antibody; hCAP-E antibody; hCAPE antibody; PRO0324 antibody; SMC 2 antibody; SMC protein 2 antibody; SMC-2 antibody; SMC2 antibody; SMC2 L1 antibody; SMC2_HUMAN antibody; SMC2L1 antibody; Structural maintenance of chromosomes (SMC) family member chromosome associated protein E antibody; Structural maintenance of chromosomes 2 antibody; Structural maintenance of chromosomes 2 like 1 antibody; Structural maintenance of chromosomes 2 yeast like 1 antibody; Structural maintenance of chromosomes protein 2 antibody; XCAP E homolog antibody; XCAP-E homolog antibody; XCAPE homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SMC2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • 基因功能參考文獻：
    1. SMC2 (or the condensin complex) is a novel molecular target for the treatment of MYCN-amplified neuroblastoma. PMID: 24553121
    2. SMC2 gene is altered by both frameshift mutation and loss of expression in gastric and colorectal cancers, suggesting that SMC2 gene alterations might be involved in pathogenesis of these cancers PMID: 24483990
    3. WNT signaling can directly activate SMC2 transcription as a key player in the mitotic cell division machinery. PMID: 23095742
    4. Studies indicate that tagged SMC2 subunit of the condensin complex with the streptavidin-Binding Peptide optimising efficacious use of this tag for protein analysis. PMID: 21194474
    5. human SMC2 hinge domain with short coiled coils was cloned, expressed, purified and crystallized in the orthorhombic space group C222 in native and SeMet-derivatized forms PMID: 20823528

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  • 亞細胞定位：
    Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • 蛋白家族：
    SMC family, SMC2 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14011

    OMIM: 605576

    KEGG: hsa:10592

    STRING: 9606.ENSP00000286398

    UniGene: Hs.119023