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SMOX Antibody, FITC conjugated

  • 中文名稱：
    SMOX兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA021844LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SMOX Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SMOX antibody; C20orf16 antibody; SMO antibody; UNQ3039/PRO9854 antibody; Spermine oxidase antibody; EC 1.5.3.16 antibody; Polyamine oxidase 1 antibody; PAO-1 antibody; PAOh1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Spermine oxidase protein (268-353AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
  • 基因功能參考文獻：
    1. Data suggest that intermolecular disulfide bond links spermine oxidase (SMOX) molecules to form the homodimer and plays a critical role in the stabilization of the overall three-dimensional SMOX structure. PMID: 29138259
    2. These results indicate a protective role for miR-124 through the inhibition of SMOX-mediated DNA damage in the etiology of H. pylori-associated gastric cancer. PMID: 27041578
    3. effect of Tat on Nrf2 activation in human neuroblastoma cells and the role of NMDA receptor and spermine oxidase on Tat-induced nuclear factor erythroid 2-related factor 2 (Nrf2) activation PMID: 26895301
    4. During H. pylori infection, the enzyme spermine oxidase (SMOX) is induced, which generates hydrogen peroxide from the catabolism of the polyamine spermine, and increases gastric cancer risk. PMID: 25174398
    5. study postulates a mechanism for SAT1 and SMOX down-regulation by post-transcriptional activity of miRNAs. PMID: 24025154
    6. Tat was found to induce reactive oxygen species production and to affect cell viability in SH-SY5Y cells, these effects being mediated by spermine oxidase (SMO) PMID: 23665428
    7. Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. PMID: 21839041
    8. each gene was associated with at least one main outcome: anxiety (SAT1, SMS), mood disorders (SAT1, SMOX), and suicide attempts (SAT1, OATL1). PMID: 21152090
    9. Spermine oxidase (SMO) has a role in response to BENSpm and CPENSpm in breast tumor cells PMID: 20946629
    10. Increased expression of spermine oxidase is associated with ulcerative colitis. PMID: 20127992
    11. the genetic and epigenetic factors examined in this study show little influence on the expression level of SMOX in suicide completers. PMID: 20059804
    12. Knockdown studies suggest that induction of SSAT and SMO is correlated with the antiproliferative effects of BENSpm with 5-FU or paclitaxel in MDA-MB-231 cells. PMID: 19727732
    13. Fully protonated forms of the inhibitors and the unprotonated form of an amino acid residue with a pK(a) of approximately 7.4 in the active site are preferred for binding. PMID: 20000632
    14. There are at least four isoenzymes of human PAO, each with different biochemical characteristics and roles in polyamine catabolism PMID: 12398765
    15. The results of these studies are consistent with the hypothesis that polyamine oxidase 1 (PAOh1/SMO) represents a new addition to the polyamine metabolic pathway. PMID: 12727196
    16. SSAT and SMO(PAOh1) activities are the major mediators of the cellular response of breast tumor cells to polyamines while PAO plays little or no role in this response PMID: 16207710
    17. Tissues from patients with prostate cancer and prostatic intraepithelial neoplasia exhibit increased spermine oxidase expression. PMID: 18302221
    18. analysis of nuclear localization of human spermine oxidase isoforms PMID: 18422650

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  • 亞細胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 組織特異性：
    Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15862

    OMIM: 615854

    KEGG: hsa:54498

    STRING: 9606.ENSP00000307252

    UniGene: Hs.433337