SNRPD1 Antibody

說明書

產品詳情

Uniprot No.：

P62314
基因名：

SNRPD1
別名：

AA407109 antibody; AL023031 antibody; HsT2456 antibody; Sm D1 antibody; Sm-D autoantigen antibody; Sm-D1 antibody; Small nuclear ribonucleoprotein D1 polypeptide antibody; Small nuclear ribonucleoprotein Sm D1 antibody; SmD autoantigen antibody; SMD1 antibody; SMD1_HUMAN antibody; snRNP core protein D1 antibody; SNRPD antibody; Snrpd1 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SNRPD1
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
基因功能參考文獻：
1. Data show that the elevation of cerebrospinal fluid anti-Sm antibodies through transudation from systemic circulation due to damaged blood-brain barrier (BBB) plays a critical role in the pathogenesis of acute confusional state (ACS). PMID: 25273532
2. The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
3. Overexpression of SNRPD1 is associated with highly aggressive breast cancers. PMID: 23358685
亞細胞定位：

Cytoplasm, cytosol. Nucleus.
蛋白家族：

SnRNP core protein family
數據庫鏈接：

HGNC: 11158

OMIM: 601063

KEGG: hsa:6632

STRING: 9606.ENSP00000300413

UniGene: Hs.464734