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SPC25 Antibody, HRP conjugated

  • 中文名稱(chēng)：
    SPC25兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA881019LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) SPC25 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPC25
  • 別名：
    AD024 antibody; hSpc25 antibody; Kinetochore protein Spc25 antibody; SPBC25 antibody; SPC25 antibody; SPC25_HUMAN antibody; spindle pole body component 25 homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Kinetochore protein Spc25 protein (1-224AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
  • 基因功能參考文獻(xiàn)：
    1. SPC25 overexpression significantly increased the cancer stem cell properties and invasion of A549 cells. PMID: 29432994
    2. SPC25 expressed by extracellular matrix stiffening is required for lung cancer cell proliferation. PMID: 29709477
    3. SPC25 overexpression is associated with Breast Cancer. PMID: 27197203
    4. hSPC25 is an essential kinetochore component that plays a significant role in proper execution of mitotic events PMID: 14699129
    5. the Spc24, Spc25, Nuf2, and Ndc80/Hec1 complex is a faithful copy of the endogenous Ndc80 complex PMID: 15961401

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    SPC25 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24031

    OMIM: 609395

    KEGG: hsa:57405

    STRING: 9606.ENSP00000282074

    UniGene: Hs.421956